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reported that IGF1R stimulates M1 polarization through toll-like receptor (TLR4)/NF-B pathway in intracerebral haemorrhage (ICH) induced mice [141]

Excess glucose in circulation interacts with the microvascular and endothelial dysfunction caused by hyperglycemia is strongly associated with inflammatory signaling and oxidative stress

HIF overexpression has been associated with radiotherapy resistance and decreased survival of cancer patients related to tumor hypoxic states [22, 94,95,96,97]

This study represents a conceptual advance in stem cell biology by linking population-level transcriptomic snapshots to predictive fate modelling, thereby resolving early erythroid commitment and uncovering previously unappreciated lineage coupling and regulatory mechanisms