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Compounded tirzepatide offers an alternative pathway that has become increasingly popular

Individuals who benefit most from B12 shots for maintenance are those with adequate overall nutrition who simply need periodic B12 replenishment

doi: 10.1056/NEJMoa1506348 10 HariPRajRVOlteanuH

Vitamin B12 often occurs in a combination with deficiency of vitamin B6, or folate deficiency anemia

Six trials totaling roughly 900 participants are summarized in Stier et al

In the SURMOUNT-1 phase-3 trial, tirzepatide produced dose-dependent weight loss reaching about ~21% of total body weight at the 15 mg dose, substantially more than placebo, with gastrointestinal symptoms the most common adverse events [6] [7]