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This issue is especially important for therapies directed at mitochondriaorganelle crosstalk, because the balance between reversible stress adaptation and irreversible bioenergetic collapse is strongly time-dependent, and the therapeutic window in patients is often substantially later than in experimental studies

A 44-amino-acid peptide requires substantially more processing

Nature 438 (7064): 9093

doi: 10.1016/j.ccr.2023.215481 132 DiercksCSYaghiOM

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