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Indeed, pharmacological intervention with a glycolytic inhibitor dichloroacetate has significantly reduced SU11274-promoted increase in melanoma-initiating cells and decreased their tumorigenicity [69]

High proline content (three consecutive prolines at positions 3-5) introduces conformational constraints

The riskbenefit assessment for wellness or anti-aging interventions may differ substantially from that applied to disease-specific therapeutic indications, given the differing clinical objectives and risk tolerances