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Steroids 74 , 669674 (2009)

Resveratrol, a promising pigment-lightening flavonoid found in red wine, was recently found to suppress TYR expression not via the inhibition of MITF expression, but by directly inhibiting TYR activity by a post-translational modification that reduces the levels of fully mature TYR protein (119)

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By inhibiting IKK activity, it prevents IB degradation, NF-B nuclear translocation, and pro-inflammatory gene expression

Brain aging increases sensitivity to OS and decreases the effectiveness of antioxidant defenses, causing functional deficiencies, inflammation, decreased elasticity and greater susceptibility to the etiological factors involved in the pathogenesis of neurodegenerative disease (Federico et al., 2012