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Mitochondrial autophagy, or mitophagy, includes selective sequestration of damaged mitochondria by the autophagosome and their degradation in the lysosome

By focusing on a subset of aged degus that show AD-like behavioral deficits and correlative neuropathology, we establish outbred degus as a natural model of sporadic AD and demonstrate the potential importance of wild-type outbred genetic backgrounds for AD pathogenesis. This study was motivated by the need to settle earlier debates of whether degus can be a useful natural model of AD