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In these contexts, the maladaptive effects of trained immunity may exacerbate disease pathology

Cancer Res (2014) 74(16):437887.10.1158/0008-5472.CAN-14-0792 10 XueBWuYYinZZhangHSunSYiTet alRegulation of lipopolysaccharide-induced inflammatory response by glutathione S-transferase P1 in RAW264

This trend can be observed in the advanced fields of CAR T-cell therapy, bsAbs, checkpoint agonists, cytokine targeting, and microbiome interventions, which reflect a new system of rapid change in therapeutics