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GR1 is present in the cytosol and peroxisomes and GR2 in mitochondria and chloroplasts (Mller-Schssele et al., 2020)

CONTENTS Preface Pharmacokinetic & toxicokinetic Pathophysiology Clinical manifestation Differential diagnosis Diagnosis Treatment Management Specific population Going further References Preface Acetaminophen (paracetamol) poisoning is the leading cause of acute liver failure worldwide, accounting for 46% of ALF cases in some areas

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Alcohol Consumption: The liver uses a massive amount of glutathione to process alcohol, often leaving it depleted the next day

Nat Rev Drug Discov 5(3):185186

Lindemann et al