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Di Silverio F, Gentile V, De Matteis A, Mariotti G, Giuseppe V, Luigi PA, et al

Other factors explain miliary TBs changing epidemiology, such as the AIDS pandemic, the availability and widespread use of computed tomography and the increasing frequency of solid organ transplants (Sharma and Mohan 2017

Notably, cytokines induce significant upregulation of genes involved in IFN- signaling, NF-B regulation, antigen presentation, and free radical scavenging, further linking oxidative stress to beta-cell fragility and T1D pathogenesis ( 2.2 Experimental and epidemiological evidence linking oxidative stress to type 1 diabetes There is substantial evidence supporting a pathogenic role for oxidative stress in T1D

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Thus, there is a need for further randomized, placebo-controlled studies to obtain more reliable results on ALA effectiveness

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