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Description

Improvement in the water solubility of drugs with a solid dispersion system by spray drying and hot-melt extrusion with using the amphiphilic Polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer and d -mannitol

J Hypertens Suppl 23:917

Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus

However, long-term safety data is limited

The patients were aged between 45 and 60 years and were not undergoing any other dermatological treatment (whether topical, with injectables or technologies)