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3.5 GHK-Cu regulated the SIRT1/STAT3 pathway SIRT1, which is closely associated with cellular metabolism and stress responses, also interacts with the STAT3 pathway (Figures 6AD, DSS-induced mice exhibited significantly increased SIRT1 expression and decreased p-STAT3 expression compared to the Control group

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However, inhibitors of cytokinin oxidase or dehydrogenase, enzymes that degrade cytokinins, have been shown to improve HS mitigation [145]