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Increased FDX1 activity and mitochondria-dependent energy metabolism are strong inducers of the cytotoxic effects of elesclomol-mediated cuproptosis (Tsvetkov et al., 2019) and inhibit Fe-S cluster biosynthesis (Tsvetkov et al., 2019)

Hepatitis C Virus Core Protein, Cytochrome P450 2E1, and Alcohol Produce Combined Mitochondrial Injury and Cytotoxicity in Hepatoma Cells

Meanwhile, pro-caspase-1 will be recruited and activated by the ASC domain of the inflammasome, cleaves itself into active caspase-1, which is involved in the maturation of interleukin precursor molecules, resulting in a widespread inflammatory response [17, 20]

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doi: 10.3389/fnins.2022.1042442 Received 12 September 2022 Accepted 21 October 2022 Published 15 November 2022 Volume 16 - 2022 Edited by David Martn Hernndez, Centro de Investigacin Biomdica en Red de Salud Mental (CIBERSAM), Spain Reviewed by Sara De Martin, University of Padua, Italy