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doi: 10.1038/s41598-018-33358-2 62 ZimetbaumP

In a 2022 randomized, double-blind study, researchers assessed the efficacy of topical silymarin versus 2% hydroquinone cream as a melasma treatment

10.1016/j.trac.2019.115638 288 ZhengC.KeW.YinT.AnX

By interacting with mitochondria, it induces an imbalance in the activities of endogenous antioxidants resulting in an increased accumulation of ROS and lipid peroxides in cancer cells