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Dendritic cell maturation and cross-presentation: timing matters

Cancer and the Microbiome-Influence of the Commensal Microbiota on Cancer, Immune Responses, and Immunotherapy

Additionally, we show that KRAS G13D/ + and KRAS G13D/ cells have a distinct metabolic profile characterized by dysregulation of TCA cycle, up-regulation of glycolysis and glutathione metabolism pathway as well as increased glutamine uptake and acetate utilization

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The underlying logic is that chemotherapy, through ROS-induced ICD, creates an in situ vaccine at the tumor site, effectively activating the immune system

Immediately prior to infection, the temperature setpoint was either maintained at 37C or changed to a range of temperatures between 31C and 38.5C across multiple experiments with each condition performed in duplicate (Table 1