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264,265,266 The hypothalamus contains various neurons that respond to different nutritional signals and hormones, like GLP-1, to regulate food intake

Our findings support a sustained loss of proteostasis in aged T cells, consistent with studies reporting the accumulation of misfolded proteins 45,46 , reduced activity of proteolytic systems such as the proteasome 47 and autophagy 48 , and altered chaperone expression 49

Early-stage literature suggests activity in growth factor signaling pathways, though clinical efficacy in humans remains limited and largely investigational

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Additionally, a higher expression of programmed death 1 (PD-1) on NK membranes and the binding to its ligand on MM cells contribute to the impaired immune response and MM progression [41]