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10.1523/JNEUROSCI.3968-04.2004 150 YangC.WangC.WangM.QinX.HaoG.KangM.et al (2021)

10.1111/j.1432-1033.1994.tb18666.x 25 DixonD

3 Once activated by infection, neutrophils are rapidly recruited to sites of inflammation in the lungs, where they produce and secrete cytokines, enzymes, including elastase (NE), reactive oxygen species (ROS) by oxidative burst, and finally release DNA to form neutrophil extracellular traps (NETs)

This method is referred to as the free capture biotin-streptavidin assay method, and it is vulnerable to biotin interference

8,9 Hyperphosphorylated tau detaches from microtubules and sticks to other tau molecules, generating threads that eventually unite to create tangles inside neurons, known as NFTs

However, astrocytes and microglia are profoundly altered structurally and functionally in the aged brain, and these changes extend to the cells and structures they support (Figure 2A)