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Compared with the D/A and LRKY/AAAA mutants, the FIL/AAA and GK/AA mutants presented significantly weaker proteinprotein interactions, further confirming the importance of FIL residues but not residues in the TM4 region in homotrimer formation (Supplementary Fig

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The type of tear and the location, as well as the health and age of the patient, will determine whether a meniscus tear is better treated with surgery or non-surgical interventions