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Lymph node macrophages drive immune tolerance and resistance to cancer therapy by induction of the immune-regulatory cytokine IL-33

-tocoferol (0.4 mM) was applied as positive control

An in-depth investigation suggested that IGF-1 stimulates human articular chondrocytes to synthesize proteoglycans by activating the PI3K/Akt/mTOR signaling pathway without activating the Ras/Raf/MEK/ERK pathway [18]