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In fact, it is not only tumor microenvironments which can educate immune cells since for instance, the GM-CSF can license murine and human monocytes toward their immunosuppressive phenotypes through the PI3K/AKT/mTOR signaling pathway [90]

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Some patients may be able to benefit from weekly sessions, while others might require treatments only once a month

Also, ketorolac is contraindicated for use by patients who take aspirin or another NSAID because of the cumulative risk of inducing serious NSAID-related side effects