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96 It has been shown that hepatocellular carcinoma cells are resistant to sorafenib, a novel multi-targeted oral drug for the treatment of tumors, 97 which is acquired through transcriptional regulation of genes involved in lipid ROS and iron metabolism

10.3389/fimmu.2022.877650 51 HuM.YinH.MitraM

Medicina (Kaunas) 60(5):815

We found that the intensity of GFAP was significantly greater in SOD1 G93A mice than in WT mice and that this increase was significantly reduced by KDS12025 treatment (Fig

Microbial beta-glucuronidase and other enzymes can deconjugate selected metabolites, allowing them to be reabsorbed through enterohepatic circulation

Excessive iron accumulation in the brain intensifies oxidative stress, amplifies lipid peroxidation, and promotes ferroptosis, thereby accelerating neuronal degeneration (Zhang et al., 2024)