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Oral bioavailability of DSIP is expected to be very low because stomach acid and gastrointestinal proteases rapidly cleave the nine-amino-acid chain before absorption

Results Pre-pubertal colitis in mice affects pubertal timing and ovarian function In order to examine the mechanisms through which early-life inflammation-associated energetic demands affect reproductive function, we adopted a mouse model of temporary colitis in newly-weaned female mice by administration of dextran sulfate sodium (DSS)

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Separate human evidence from preclinical or anecdotal claims

Vomiting odds increased dramatically with an odds ratio of 9.57 compared to placebo