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Highlighting Immune System and Stress in Major Depressive Disorder, Parkinsons, and Alzheimers Diseases, with a Connection with Serotonin

Down-regulation of DJ-1 augments neuroinflammation via Nrf2/Trx1/NLRP3 axis in MPTP-induced Parkinson's disease mouse model

Donnelly, SC

Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes

In contrast, ACSL4 is a key enzyme that catalyzes the biosynthesis of polyunsaturated fatty acidcontaining phospholipids, thereby promoting ferroptosis (44)

Although studies with cereblon-based PROTACs are still scarce, it is expected that long-term clinical use of this type of degrader could lead to the emergence of mutations that prevent PROTAC from binding to cereblon, thus preventing poly-ubiquitination of the target protein