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In turn, phosphorylation of STAT1 leads to its translocation to the nucleus where it binds to the consensus gamma-activated sequence (GAS) sites in the promoters of several target genes and activates their expression (196)

GPX4 inhibition effectively sensitizes resistant cancer cells to ferroptosis, particularly in malignancies such as clear-cell carcinomas, where oxidative stress is a critical vulnerability [16]

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This distinguishes correct from incorrect peptide IDs in a manner analogous to the widely used Percolator algorithm 53 , though employing a distinct machine learning algorithm

Transfection mixes were prepared using 0.25 nM siRNA and 2.5 l Lipofectamine RNAiMAX Transfection Reagent (Cat

The column oven temperature was 45C