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Limitations of oral supplementation: Poor and unpredictable absorption of Vitamin B12 Patient non-compliance due to long duration of treatment High cost of therapy without assured results Limitations of parenteral supplementation: Painful and inconvenient, leading to patient non-compliance Time consuming & inconvenient clinic visits for the administration High cost of therapy Oral is not absorbed well

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It accelerates the healing of corneal epithelial defects and prevents neovascularization, which is crucial for preserving corneal clarity

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Normally, the skins outer layer, the stratum corneum, does a great job of keeping things out