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The evidence base is preclinical for IGF-1 LR3 specifically, with adjacent human data from native rhIGF-1 (mecasermin/Increlex)

10.1111/j.1468-1331.2004.00938.x 5 AlmawiW

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Fatigue: A sense of lethargy reported early on, possibly due to metabolic shifts

It helps transport fatty acids into the mitochondria of cells, where they are burned for energy