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Participants lost an average of 17.1% body weight at 48 weeks

Individual results vary based on starting weight, adherence, diet, exercise, and other factors

The secondary structure prediction showed the dominance of -helices indicative of PsomGSTs as structurally stable and elastic proteins

5.4 Tryptophan depletion and kynurenine accumulation: an immunosuppressive axis The profound depletion of tryptophan coupled with significant accumulation of its catabolite kynurenine (Kyn) forms a potent immunosuppressive axis in the colorectal cancer tumor microenvironment, thus remodeling immune cell function and facilitates tumor immune evasion ( Figure 3 )