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While rare, severe skin toxicities do occur and can be life-threatening including edema, oozing and separation of the dermis

Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: Results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis [ESTEEM] 1)

10.1111/jcmm.15809 69 Malek MahdaviA.MahdaviR.KolahiS

Notwithstanding the strides achieved in genetic manipulation and regenerative technologies, L-DOPA or compounds related to dopamine metabolism such as MAO-B inhibitors remain as the major modes of palliative care for PD patients 39,56

220 This may be due to a marked increase in the activity of arginase induced by IL-4 and IL-13 and a marked increase in the downstream product putreamine in allergen-stimulated lungs