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Cytochrome P450 2E1 null mice provide novel protection against cisplatin-induced nephrotoxicity and apoptosis

Price VH, Hordinsky MK, Olsen EA, Roberts JL, Siegfried EC, Rafal ES, Korman NJ, Altrabulsi B, Leung HM, Garovoy MR, Caro I, Whiting DA (2008) Subcutaneous efalizumab is not effective in the treatment of alopecia areata

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From a molecular point of view, the necroptosis pathway is initiated by auto- and trans-phosphorylation of RIPK1 and RIPK3 at Ser-227, resulting in stimulation of their kinase activity and assembly of a heterodimer protein complex termed necrosome via their RIPK homotypic interaction motif domains (Fulda, 2013

Overexpression of KDM3B decreased H3K9 methylation (related to transcriptional inhibition) and upregulated the expression of SLC7A11, thus enhancing resistance to Erastin-induced ferroptosis