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Additional information Peer review information : Nature Communications thanks Kazuei Igarashi, David Nielsen, and the other anonymous reviewer(s) for their contribution to the peer review of this work

For instance, oxidized glutathione (GSSG) has recently been shown to suppress the expression of the NDM-1 metallo--lactamase gene, thereby restoring carbapenem susceptibility in E

Epitalon is primarily studied for its ability to activate telomerase, the enzyme responsible for maintaining telomere length, and has been investigated in preclinical and limited clinical studies as a potential geroprotective agent

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A systematic division of different strategies to target -syn thus separates stabilizing the physiological conformation of -syn, decreasing its expression, inhibiting its aggregation, and increasing intracellular clearance, from transmission-directed approaches including inhibiting uptake by neighboring cells and enhancing extracellular clearance mechanisms (Figure 2