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Through microbial action, these substrates are converted into various metabolites that may be advantageous or harmful to the host, including SCFAs, choline metabolites, vitamins, lipids, phenolic compounds, cortisol, genetic materials, and phytoestrogens (8486)

The disability rate increases dramatically with the course of the disease, reaching 70% at 3 years in untreated patients, and the systemic complications reduce life expectancy by 1015 years (2)

Publicly available datasets used in this study are at DepMap ( Extended Data Fig

Available publications report on CRHs ability to enhance proliferation and expression toward IL-2 receptors and on its ability to stimulate T and B lymphocyte proliferation processes

LC, loss of cilia

Cells were fixed with 4% PFA for 15 min, permeabilized with 0.5% Triton X-100 in PBS for 5 min and blocked with blocking buffer (10% normal goat serum in PBS) for 30 min