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The two-hit hypothesis in the context of aberrant neuroplasticity and environmental factors (such as trauma) is elegantly described in a review article by Rauschenberger and colleagues [ 159 ]

Following hybridization, the slide was washed with 0.2% SDS/2 SSC at 42 C for 5 minutes and then washed with 0.2 SSC at room temperature for 5 minutes