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Administration of DTA (25 or 50 ng/g, 2 x, i.p.) to CCl 4 -injured Lrat YFP-Col1a1-DTR mice caused ablation of aHSCs within 24h in a dose dependent manner (60% to 90%, respectively), as shown by the disappearance of YFP + Desmin + cells, and downregulation of Col1a1, YFP, DTR, and Cre mRNA, and attenuation of liver fibrosis at 3 days

This can culminate in geographical atrophy which are accumulations of atrophic RPE and photoreceptor cells causing loss of vision (265)

One study of herbal eye drops that included rosmarinic acid suggested that it could prevent cataracts in animals

Lentz SR, Sobey CG, Piegors DJ, Bhopatkar MY, Faraci FM, Malinow MR, and Heistad DD (1996)

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Condensing content Copper homeostasis is crucial for normal physiological functioning, playing pivotal roles in energy metabolism, antioxidant defense, and immune regulation, while also being intimately involved in the onset and progression of neurodegenerative diseases