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Microplates are then incubated for 1 - 20 hours, depending on the cell type

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These findings indicate that just as HIF-1 generally affects glucose metabolism in hypoxia, HIF-2 also plays a distinct role in glutamine metabolism to promote metabolic adaptation in hypoxia (Fig

In oxygen-rich regions, LDHB catalysis in oxidative cancer cells results in the conversion of lactate to pyruvate, which then enters the TCA cycle together with NADH via the malateaspartate shuttle

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