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This is typically done when FDA-approved drugs dont work, often because of allergies, delivery methods or dosage strengths

The molecule carries an -aminoisobutyric acid (Aib) substitution at position 2 that blocks DPP-IV cleavage, conferring complete resistance to the proteolytic step that inactivates native incretins within minutes

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As a result, many patients develop post-viral insulin resistance, meaning their cells can no longer efficiently absorb glucose from the bloodstream to create energy

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