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The complexes I and III of mitochondrial ETC produces superoxide anion (Rodriguez and Redman, 2005)

Lipid peroxidation has been identified as a key driver of ferroptosis

2 Early symptoms may include gastrointestinal disturbances such as nausea, vomiting, and abdominal pain, which may progress to more severe manifestations, including jaundice, hepatic encephalopathy, and coagulopathy in patients with advanced liver injury

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This ROS overproduction, compounded by elevated iron levels, enhances lipid peroxidation, a key feature of ferroptosis