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Dual targeting of Nur77 and AMPK by isoalantolactone inhibits adipogenesis in vitro and decreases body fat mass in vivo

Patients with SCD have increased rates of venous and arterial thrombotic events ( Unraveling these pathophysiological targets has provided insights on clinical trials on anti-platelet and anti-adhesion agents, as well as anti-coagulation factors for the prevention of acute VOC pain in SCD (Telen, 2016

Segal R, Mozes E, Yaron M, Tartakovsky B: The effects of methotrexate on the production and activity of Il-1

871 Oxidative stress is characterized by MDA and 4-HNE, and their roles in cartilage degeneration and subchondral bone remodeling during OA development have received extensive attention

Furthermore, it also displays tissue-specific functions, including controlling skin function, adipocyte differentiation in obesity, and lipid profiles in cardiovascular disorders [33]

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