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The consequence is that every dose of MT-II activates the entire suite of melanocortin effects simultaneously: melanogenesis through MC1R, appetite suppression through MC3R and MC4R in the arcuate nucleus, sexual arousal through MC4R in the paraventricular nucleus, and exocrine effects through MC5R

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Although cardiac side effects are rare and werent reported in our study, should be always suspected and ECGs and echocardiograms are recommended before and during KD therapy

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