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The first structure of the AR LBD was solved with the AR in complex with the potent synthetic androgen R1881 (metribolone) (Figure 3A) and shows the AR in an agonist conformation with the ligand inside of the LBP formed by H3, H5, and H11 (PDB: 1E3G) (Figure 2D and 3B) 57

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Dieterich W, Ehnis T, Bauer M, et al

Synthesis and post-translational modification of the androgen receptor in LNCaP cells