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Andrea M, Riccardo T, Vincenzo F, Marco C, Andrea M

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Unlike other Na + -dependent MFS transporters, such as MelB 37 and MFSD2A 38,39,40 , where the Na + site forms part of the substrate-binding cavity, the OCTN2 Na + -binding site is buried within a solvent-filled cavity in the N-terminal bundle

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Research has demonstrated that antioxidants, such as LC, can suppress the NF-B activation pathway, hence diminishing oxidative and inflammatory stress (Conner and Grisham 1996