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doi: 10.1172/JCI12939 25 BuendiaI.MichalskaP.NavarroE.GameiroI.EgeaJ.LeonR

Glutathione also helps to protect against DNA damage and is necessary for supporting the immune system and is required for replication of the Lymphocyte immune cells

HO-1, heme oxygenase-1

Withdrawal from GABAergic acting sedative-hypnotic drugs causes acute GABA-under-activity as well as glutamate over-activity which can lead to sensitization and hyper-excitability of the central nervous system, excito-neurotoxicity and increasingly profound neuroadaptions. Wikipedia Kindling (sedative-hypnotic withdrawal) Similarities Between Kindling in ME/CFS and Other Kindling Disorders ME/CFS shares many symptoms with benzodiazepine withdrawal syndrome including: agitation, chest pain, dizziness, fatigue and weakness, flu-like symptoms, irritable bowel syndrome, hot and cold flushes, orthostatic intolerance, restless leg syndrome, stiffness, tachycardia, sensitivity to touch and sound, indecision, etc

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Sivakumar D et al