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BELN supplementation also improves liver dysfunction and insulin resistance in NAFLD, which is accompanied by a reduction in AST and ALT levels and fat deposition as well as a downregulation in acetyl-CoA carboxylase 1 (ACC1) and fatty acid synthase (FAS) expression (252)

However, when ROS levels increase, they can become harmful, leading to oxidative stress and disease

Also, a phase III randomized placebo-controlled trial demonstrated that another compound protective against oxidative stress, dexpramipexole, did not improve motor function in ALS patients (Cudkowicz et al., 2013)

DOI:10.1016/j.coi.2019.05.006 19

Book 11, e0166

10.3389/fimmu.2021.754413 2