9595 - 9601, Journal articles | 2024 Sims M
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Phenytoin accelerates metabolism of vit.D3 and lead to osteomalacia Therapeutic benefits: To treat neonatal jaundice - phenobarbitone can be given to infant soon after birth to induce hepatic glucuronyltransferase (Bilirubin is conjugated and excreted) - In Cushings syndrome (Abnormally high levels of cortisol) phenytoin may reduce the manifestations by enhancing degradation of steroids Chronic poisoning : faster metabolism of accumulated poisonous substance Vegetables like cabbage ,spinach etc can induce microsomal enzymes and promotes the rapid elimination of the drugs ENZYME INHIBITION Certain drug substrates inhibit cytochrome P450 enzyme activity cimetidine and ketoconazole bind tightly to the P450 heme iron reduce the metabolism of endogenous substances competitive inhibition
Nihon Naika Gakkai Zasshi
The distinct physical activity patterns observed in ME/CFS, characterized by reduced activity intensity but not increased sedentary behavior, further highlight the link between PEN and metabolic dysfunction, likely driven by issues with energy metabolism (Newton et al., 2011)
Drug-Disease Interactions Kidney Disease: Patients suffering from kidney disease should be cautious while using Eldervit 12 Injection as high doses of vitamin C can lead to kidney stones in susceptible individuals