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( D ) Metabolomic analysis on livers from control and hepatic GSH-depleted mice ( n = 7)

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Forbes SC, Candow DG, Little JP, Magnus C, Chilibeck PD

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Further investigation revealed minimal impact of Tripterygium wilfordii on NLRP3/caspase-1 levels in MPTP-treated Nrf2-KO mice, suggesting that the extract may exert its anti-PD effects by activating Nrf2 to subsequently inhibit the NLRP3 inflammasome (Figure 4)