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As both pathways are upregulated in many cancers, strategies which target both glutamine metabolism and mTORC1 signaling have shown synergistic effects against cell growth and proliferation [99]

Its downstream target, TRIM25, significantly promotes ferroptosis in bladder cancer cells and inhibits tumor growth 238

It is believed that the inhibition of base excision repair induces radiosensitization driven on by treatment with a PARP1 inhibitor

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In psoriatic skin, NF-kB is constitutively activated, meaning it stays turned on even without an ongoing trigger

Phase II trial of pemetrexed plus gemcitabine in patients with locally advanced and metastatic nonclear cell renal cell carcinoma