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Incipient oxidative stress is associated with increased hippocampal protein levels of TOP2 and expression of early response genes (ERGs) While excessive ROS is associated with decreased performance in cognitive function, physiological concentrations of ROS are necessary to regulate activity-dependent neuronal plasticity 67

Some trials show it outperforms metformin on certain markers

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Validation of Interaction Specificity The specificity of protein interactions is critical for reliable biological interpretations

Amytriptyline downregulation of prkcg was examined by Tai et al