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DED is associated with an imbalance in Th17/Treg cells, leading to increased Th17 polarization and secretion of pro-inflammatory cytokines like IL-17, causing epithelial damage (Ratay et al., 2017)

Solution: Use a low-and-slow approach

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In guinea pigs, the administration of curcumin and encapsulated DEX prior to treatment effectively mitigated the ototoxic effects of cisplatin, thereby safeguarding auditory function across all frequencies

The insight that changed this view is that when glucagon receptor activation occurs alongside GLP-1 activity, the net effect is a shift toward increased energy expenditure and fat oxidation rather than hyperglycemia