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The role of ACTH and corticosteroids for sepsis and septic shock: an update

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Moxifloxacin given in a pulsed manner (400 mg/day for 5 days, repeated every 8 weeks for a total of 6 courses) has been shown to reduce ECOPD by 25% 136

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There are two main ways to avoid excessive interaction of the gut microbiota with TLRs to prevent activation of the intestinal and in some cases systemic immune response: i) decreasing the expression of TLRs, and ii) moving TLRs from the plasma membrane into lysosomes (Semin et al., 2021)