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When Patients May Benefit From Methylene Blue Patients with Persistent Cognitive or Neurological Complaints Some patients come in describing issues that are hard to quantify on paper brain fog, memory lapses, or slowed processing

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Thus, the observed formation of MeHg-hCys complexes at near physiological conditions of blood plasma provides a feasible pathway by which MeHg + is delivered to the brain (Figure 2), where adverse biochemical processes including the inhibition of the selenoprotein glutathione peroxidase 4 (GPx) will then unfold (Chen et al., 2023)

Of note, intra-follicular endocrine dysregulation is a plausible convergence layer for heterogeneous clinical phenotypes (e.g., endometriosis-, PCOS-, or age-associated follicular dysfunction), making it a rational target for integration rather than treating serum hormones as interchangeable proxies for the follicular milieu [255, 256]