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In support of the idea that cross-protective immunity exists, recent HCoV infections were found to be associated with less severe COVID-19 upon infection with ancestral SARS-CoV-2 [103], and infection with SARS-CoV-2 of any variant was also associated with a reduced incidence of subsequent HCoV infection

Binding of VEGF-A to VEGFR2 results in tyrosine phosphorylation in VEGFR2 and subsequent activation of cellular substrates including extracellular-regulated kinase 1/2 (ERK1/2), members of the mitogen-activated protein kinase superfamily, which regulate cell proliferation, differentiation and survival (5)

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