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This mechanism also works without the so-called intrinsic factor

Biochim Biophys Acta 460:299307 Leary SC, Hill BC, Lyons CN, Carlson CG, Michaud D, Kraft CS, Ko K, Glerum DM, Moyes CD (2002) Chronic treatment with azide in situ leads to an irreversible loss of cytochrome c oxidase activity via holoenzyme dissociation

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Nucleic Acid Res

Sciatica symptoms can vary widely depending on where and how the nerve is affected

This distinction affects its chemistry, analytical testing, formulation and interpretation